Melissa Krebs

Associate Professor, Chemical and Biological Engineering

Melissa KrebsThere is a critical need for replacement tissues due to organ failure and tissue loss. The field of tissue engineering seeks to regenerate diseased or damaged tissues by providing the necessary physical, biochemical, and cellular cues that promote tissue regeneration. These approaches typically use biomaterial scaffolds, often with incorporated bioactive factors to help induce the formation of the desired tissue within a defect site. In the body, cells are influenced by a large host of factors, including soluble signals such as growth factors, insoluble signals that are components of the extracellular matrix surrounding the cells, and also the interaction of various populations of cells with each other.

Our group is interested in the development of biopolymer systems that will allow the study of cells’ interactions with their microenvironment and that can be used for tissue regeneration and therapeutics. We are investigating the controlled delivery of bioactive factors and therapeutics, the presentation of insoluble signals to cells, the effect of mechanical forces on cell behavior and tissue formation, and the influence that different cell populations have on one another. These advances will lead to improved biomaterial system design criteria. The applications that we are researching include growth plate cartilage regeneration, trabecular meshwork cell behavior that is important in glaucoma, diabetic wound healing, and bone and dental tissue regeneration. Ultimately, what we learn in our laboratory will help to improve patient therapies that are available in the clinic.


431 Alderson Hall
1613 Illinois Street
Golden, CO 80401
Office: (303) 273-3983
Fax: (303) 273-3730

Research Group

  • Bikram Adhikari, University of New Orleans
  • Michael Stager, University of New Mexico
  • Kathryn Scherrer, Colorado School of Mines

Krebs Research Group Website


  • BS, MS – University of Rochester
  • PhD – Case Western Reserve University
  • Post-Doctoral Study – Case Western Reserve University and University of Colorado Anschutz Medical Campus

Selected Publications

Google Scholar Citations Page


Honors and Awards